Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial. BMJ

(2006) and Sahin et al. (2004) is not correct. Khorram et al. randomized patients between metformin plus clomiphene and clomiphene alone. Metformin was started in the same cycle as was clomiphene. Sahin et al. did treat the patients with metformin 3 months prior to administrating clomiphene, but all patients also received clomiphene, which also makes the comparison justifiable. Both these studies together counted for 52 of 985 patients (5%) in this particular comparison. Obviously, there is no argument against more data as the estimation of the truth will thereby improve.